Description

Dexamethasone 21-Pivalate is a potent synthetic glucocorticoid ester, specifically the 21-pivalate derivative of dexamethasone. This chemical modification enhances its lipophilicity and stability, making it a crucial intermediate in the synthesis of advanced pharmaceutical formulations. It is primarily utilized by research institutions and pharmaceutical manufacturers specializing in anti-inflammatory, immunosuppressive, and oncological therapies. The compound's defined structure ensures consistent performance in the development of injectable and topical corticosteroid products.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of high-potency corticosteroid APIs (Active Pharmaceutical Ingredients).
• Anti-inflammatory Drug Research: Used in preclinical and clinical research for developing new treatments for conditions like arthritis, asthma, and dermatitis.
• Veterinary Medicine: Employed in the formulation of anti-inflammatory and immunosuppressive treatments for animals.
• Reference Standard: Serves as a certified reference standard (CRS) or working standard in analytical laboratories for quality control and method validation.
• Dermatological Preparations: A precursor in the manufacture of topical creams and ointments for severe skin conditions.
• Oncological Supportive Care: Used in formulations to manage inflammation and edema associated with cancer and its treatment.

Basic Information

Product Name	Dexamethasone 21-Pivalate
CAS No.	1926-94-9
Molecular Formula	C26H35FO6
Molecular Weight	462.55 g/mol
Synonyms	Dexamethasone Pivalate; Dexamethasone 21-Trimethylacetate; 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-Pivalate; 16α-Methyl-9α-fluoro-1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-Pivalate; Pivalic acid ester with dexamethasone; SQ-15102; NSC-123973
EINECS	217-690-9

Quality Control

Our Dexamethasone 21-Pivalate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR for identification, and residual solvent analysis, to ensure it meets high-grade pharmaceutical standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters. We support cGMP (current Good Manufacturing Practice) standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.