Description

6Alpha-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Pivalate is a high-purity synthetic corticosteroid intermediate, specifically the 21-pivalate ester derivative of a fluorinated glucocorticoid. This compound is critical for ensuring the precise and efficient synthesis of potent anti-inflammatory and immunosuppressive active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D laboratories and manufacturing facilities specializing in the production of advanced steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of high-potency topical and systemic corticosteroids.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for novel glucocorticoid receptor agonists.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method validation in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and optimization of steroid manufacturing pathways requiring specific ester protection.
• Biochemical Research: Used in studies investigating steroid hormone action, receptor binding, and metabolic pathways.

Basic Information

Product Name	6Alpha-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Pivalate
CAS No.	1926-93-8
Molecular Formula	C₂₇H₃₇FO₇
Molecular Weight	492.58 g/mol
Synonyms	Flumethasone Pivalate; Flumethasone 21-Pivalate; 6α-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-pivalate; 6α-Fluoro-16α-methylprednisolone 21-pivalate; Flumetasone Pivalate; NSC 107679; SQ 15102; Flumethasone Trimethylacetate; Flumethasone 21-Trimethylacetate
EINECS	217-677-4

Quality Control

Our 6Alpha-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Pivalate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.