Description

Betamethasone 21-Mesylate is a key pharmaceutical intermediate and a mesylate ester derivative of the potent corticosteroid betamethasone. This compound is primarily valued for its role in the synthesis of more complex steroid-based active pharmaceutical ingredients (APIs) and prodrugs. It is essential for manufacturers and research institutions in the global pharmaceutical and life sciences sectors developing advanced anti-inflammatory and immunosuppressive therapies.

Application

• Pharmaceutical Intermediate: Critical starting material or intermediate in the multi-step synthesis of high-potency corticosteroid APIs.
• Prodrug Development: Serves as a precursor for designing prodrugs with improved solubility, stability, or bioavailability profiles.
• Research & Development: Used in biochemical and pharmacological research to study steroid metabolism, receptor binding, and structure-activity relationships (SAR).
• Reference Standard: Employed as a certified reference standard (CRS) in analytical laboratories for quality control and method validation.
• Veterinary Pharmaceuticals: Utilized in the development of anti-inflammatory treatments for veterinary applications.

Basic Information

Product Name	Betamethasone 21-Mesylate
CAS No.	1881-66-9
Molecular Formula	C24H33FO7S
Molecular Weight	484.58 g/mol
Synonyms	Betamethasone 21-Methanesulfonate; 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-methanesulfonate; Betamethasone Mesylate; NSC 39471; 21-Mesyloxy-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione; Betamethasone 21-(Methyl Sulfonate)
EINECS	Contact for details

Quality Control

Our Betamethasone 21-Mesylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting standards suitable for pharmaceutical R&D and intermediate use. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.