Description

6Alpha-Fluoro-17,21-Dihydroxy-16Alpha-Methylpregna-4,9(11)-Diene-3,20-Dione 21-Acetate is a high-purity synthetic steroid intermediate of significant importance in pharmaceutical research and development. This compound serves as a critical precursor in the synthesis of potent corticosteroid and anti-inflammatory agents, enabling precise structural modifications for enhanced therapeutic activity. It is primarily required by pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers focused on advanced steroid chemistry and novel drug discovery.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of advanced corticosteroid drugs, including anti-inflammatory and immunosuppressive agents.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new steroid-based therapeutics.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to introduce specific fluorinated and hydroxylated steroid frameworks.
• Process Development: Utilized in scaling up and optimizing manufacturing routes for complex steroid APIs (Active Pharmaceutical Ingredients).

Basic Information

Product Name	6Alpha-Fluoro-17,21-Dihydroxy-16Alpha-Methylpregna-4,9(11)-Diene-3,20-Dione 21-Acetate
CAS No.	1881-07-8
Molecular Formula	C₂₄H₃₁FO₆
Molecular Weight	434.50 g/mol
Synonyms	6α-Fluoro-16α-methylprednisolone 21-acetate; 6α-Fluoro-16α-methyl-δ⁹(¹¹)-prednisolone 21-acetate; 6α-Fluoro-16α-methyl-9(11)-dehydroprednisolone 21-acetate; 6α-Fluoro-16α-methyl-11-deoxyprednisolone 21-acetate; 6α-Fluoro-16α-methyl-δ⁹(¹¹)-cortisol 21-acetate; 6α-Fluoro-16α-methyl-9,11-dehydrocortisol 21-acetate; 6α-Fluoro-16α-methyl-11-deoxycortisol 21-acetate; 6α-Fluoro-16α-methyl-17,21-dihydroxypregna-4,9(11)-diene-3,20-dione 21-acetate
EINECS	Contact for details

Quality Control

Our 6Alpha-Fluoro-17,21-Dihydroxy-16Alpha-Methylpregna-4,9(11)-Diene-3,20-Dione 21-Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, to ensure compliance with stringent pharmaceutical-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.