Description

17-Oxodexamethasone is a key pharmaceutical intermediate and a derivative of the potent glucocorticoid dexamethasone. This compound is of significant value in the research and development of novel steroid-based therapeutics and analytical reference standards. It is primarily utilized by pharmaceutical manufacturers, research institutions, and contract development organizations engaged in steroid chemistry, anti-inflammatory drug discovery, and metabolic studies.

Application

• Pharmaceutical Intermediate: Critical synthesis precursor for the development of novel corticosteroid analogs and prodrugs.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of dexamethasone and related compounds via HPLC, LC-MS, or GC-MS.
• Biochemical Research: Serves as a tool compound in metabolic pathway studies, glucocorticoid receptor (GR) research, and investigations into steroid hormone activity.
• Process Chemistry: Employed in scaling up synthetic routes for steroid-based active pharmaceutical ingredients (APIs) under GMP or non-GMP conditions.

Basic Information

Product Name	17-Oxodexamethasone
CAS No.	1880-61-1
Molecular Formula	C22H29FO5
Molecular Weight	392.46 g/mol
Synonyms	9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 17-Oxo-dexamethasone; 11β,17,21-Trihydroxy-16α-methyl-9-fluoro-1,4-pregnadiene-3,20-dione; Dexamethasone 17-ketone; 16α-Methyl-9α-fluoro-1,4-pregnadiene-11β,17,21-triol-3,20-dione; 9α-Fluoro-16α-methyl-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione
EINECS	217-523-9

Quality Control

Our 17-Oxodexamethasone is manufactured and tested to meet high-purity standards suitable for research and pharmaceutical intermediate applications. Quality is assured through rigorous analytical controls including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and specific tests for related substances. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each batch to ensure traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.