Description

Hydrocortisone 21-(Sodium Sulphate) is the water-soluble sodium salt derivative of hydrocortisone, a key corticosteroid. This modification enhances its bioavailability and makes it suitable for formulations requiring rapid dissolution and systemic delivery. It is primarily utilized in the pharmaceutical industry for the development of injectable and topical anti-inflammatory and immunosuppressive medications.

Application

• Pharmaceutical Active Ingredient (API): Core component in the manufacture of injectable corticosteroid solutions for treating severe inflammation, allergic reactions, and adrenal insufficiency.
• Topical Formulations: Used in the development of advanced creams, gels, and lotions for dermatological conditions like eczema, psoriasis, and contact dermatitis.
• Ophthalmic Solutions: Employed in eye drops and ointments to manage inflammatory ocular conditions.
• Veterinary Medicine: Applied in anti-inflammatory and anti-shock treatments for animals.
• Research & Development: Serves as a critical reference standard and intermediate in biochemical research and the synthesis of novel steroid derivatives.

Basic Information

Product Name	Hydrocortisone 21-(Sodium Sulphate)
CAS No.	1852-36-4
Molecular Formula	C21H29NaO8S
Molecular Weight	464.51 g/mol
Synonyms	Hydrocortisone Sodium Succinate; Hydrocortisone 21-Hemisuccinate Sodium Salt; Cortisol 21-Sodium Succinate; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 21-(sodium succinate); Solu-Cortef; A-Hydrocort; Cortisol Sodium Succinate; EINECS 217-444-4
EINECS	217-444-4

Quality Control

Our Hydrocortisone 21-(Sodium Sulphate) is manufactured under strict quality systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Rotation	+140° to +150° (c=1 in water)
pH (5% solution)	6.5 - 8.5
Bacterial Endotoxins	< 0.17 EU/mg (if for injectable use)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.