Description

Pregna-1,4-Diene-3,20-Dione, 6-Chloro-9-Fluoro-11,17,21-Trihydroxy-16-Methyl-, (6α,11β,16α)- is a high-purity synthetic corticosteroid intermediate of significant pharmaceutical importance. This compound serves as a critical building block in the synthesis of potent anti-inflammatory and immunosuppressive medications. It is essential for research institutions and pharmaceutical manufacturers engaged in the development and production of advanced steroid-based therapeutics. Our supply ensures the stringent quality and consistency required for sensitive pharmaceutical applications.

Application

• Pharmaceutical Intermediate: Primary use as a key precursor in the synthesis of fluorinated corticosteroid APIs (Active Pharmaceutical Ingredients).
• Anti-inflammatory Drug Research: Serves as a core structure for developing new topical and systemic anti-inflammatory agents.
• Immunosuppressant Synthesis: Used in the manufacturing pathway for drugs that modulate the immune system.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Process Chemistry: Utilized in scale-up and optimization studies for steroid manufacturing processes.
• Academic & Biomedical Research: Supports investigative studies into steroid receptor activity and metabolic pathways.

Basic Information

Product Name	Pregna-1,4-Diene-3,20-Dione, 6-Chloro-9-Fluoro-11,17,21-Trihydroxy-16-Methyl-, (6α,11β,16α)-
CAS No.	1744-64-5
Molecular Formula	C₂₂H₂₈ClFO₅
Molecular Weight	426.91 g/mol
Synonyms	6α-Chloro-9α-fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 6α-Chloro-9α-fluoro-16α-methylprednisolone; 6-Chloro-9-fluoro-16-methylprednisolone; Fluprednisolone 6-Chloro Derivative; 6-Chloro-9-fluoro-16α-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione; 6α-Chloro-9α-fluoro-16α-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione
EINECS	Contact for details

Quality Control

Our Pregna-1,4-Diene-3,20-Dione, 6-Chloro-9-Fluoro-11,17,21-Trihydroxy-16-Methyl-, (6α,11β,16α)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and in original packaging until use to prevent degradation. For long-term storage, consider desiccants and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.