Description

6Alpha-Fluoro-17,21-Dihydroxy-16Alpha-Methylpregn-4-Ene-3,20-Dione 21-Acetate is a high-purity synthetic steroid derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in providing a reliable and consistent building block for the synthesis of potent corticosteroid APIs, ensuring downstream process efficiency and final product quality. This compound is essential for pharmaceutical R&D laboratories and manufacturers specializing in anti-inflammatory, dermatological, and immunosuppressive therapies.

Application

• Pharmaceutical Intermediate: Key precursor in the multi-step synthesis of potent fluorinated corticosteroids like Fluticasone and its analogs.
• Anti-inflammatory Drug Development: Used in research and production of advanced topical and inhaled steroids for treating asthma, eczema, and psoriasis.
• Steroid Chemistry Research: A valuable reference standard and starting material for academic and industrial research into novel steroid-based therapeutics.
• Process Chemistry: Employed in scale-up and optimization of manufacturing routes for high-value steroid active pharmaceutical ingredients (APIs).
• GMP Manufacturing: Supplied under controlled conditions for use in cGMP-compliant production lines for regulated markets.

Basic Information

Product Name	6Alpha-Fluoro-17,21-Dihydroxy-16Alpha-Methylpregn-4-Ene-3,20-Dione 21-Acetate
CAS No.	1692-75-7
Molecular Formula	C₂₄H₃₃FO₆
Molecular Weight	436.52 g/mol
Synonyms	6α-Fluoro-16α-methylprednisolone 21-acetate; Fluticasone Impurity C; Fluticasone Related Compound C; 6α-Fluoro-16α-methylprednisolone acetate; 6α-Fluoro-16α-methyl-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate; SQ 10623; 6α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate
EINECS	Contact for details

Quality Control

Our 6Alpha-Fluoro-17,21-Dihydroxy-16Alpha-Methylpregn-4-Ene-3,20-Dione 21-Acetate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and conformity to stringent specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, supporting its use in regulated pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.