Description

6α-Methyl Hydrocortisone 21-Acetate is a synthetic corticosteroid derivative, a key intermediate in the synthesis of more potent steroidal pharmaceuticals. Its value lies in providing a controlled structural modification to the hydrocortisone backbone, enabling the development of specialized anti-inflammatory and immunosuppressive agents. This high-purity intermediate is essential for pharmaceutical R&D laboratories and manufacturers engaged in the production of advanced corticosteroid APIs and novel therapeutic compounds.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the multi-step synthesis of potent topical and systemic corticosteroids.
• Anti-inflammatory Drug Research: Serves as a reference standard and starting material in the development of new steroidal anti-inflammatory agents with modified potency and metabolic profiles.
• Metabolic Studies: Used in pharmacological research to study the structure-activity relationships (SAR) of corticosteroid analogs.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for commercial steroid API manufacturing under GMP conditions.
• Reference Standard: Utilized in analytical laboratories for method development, validation, and quality control testing of related steroid products.

Basic Information

Product Name	6α-Methyl Hydrocortisone 21-Acetate
CAS No.	1625-11-2
Molecular Formula	C₂₄H₃₄O₆
Molecular Weight	418.52 g/mol
Synonyms	6α-Methylhydrocortisone 21-acetate; 6α-Methylcortisol 21-acetate; 11β,17α,21-Trihydroxy-6α-methylpregn-4-ene-3,20-dione 21-acetate; (6α,11β)-11,17,21-Trihydroxy-6-methylpregn-4-ene-3,20-dione 21-acetate; 6α-Methylprednisolone 21-acetate (related); Medrysone precursor; 6α-Methyl derivative of Hydrocortisone 21-Acetate
EINECS	Contact for details

Quality Control

Our 6α-Methyl Hydrocortisone 21-Acetate is manufactured and tested to meet stringent standards suitable for pharmaceutical intermediate applications. Quality is assured through comprehensive analytical controls including HPLC for purity, IR for identification, and specific tests for related substances. A Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment, ensuring traceability and compliance with your quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.