Description

Chlorcyclizine Hydrochloride is a pharmaceutical-grade active pharmaceutical ingredient (API) belonging to the piperazine class of antihistamines. It is valued for its potent and selective histamine H1-receptor antagonism, providing a critical building block for therapeutic formulations. This compound is essential for manufacturers in the pharmaceutical industry developing treatments for allergic conditions, motion sickness, and as a potential intermediate in further chemical synthesis.

Application

• Pharmaceutical API: Primary active ingredient in prescription antihistamine medications for allergy relief.
• Antiemetic Formulations: Used in the development of drugs to prevent and treat nausea and vomiting, particularly motion sickness.
• Veterinary Medicine: Component in antihistamine preparations for allergic reactions in animals.
• Chemical Intermediate: Serves as a key synthetic precursor for the research and development of novel piperazine-derived compounds.
• Reference Standard: Used in analytical laboratories for quality control, method development, and regulatory compliance testing.
• Clinical Research: Employed in preclinical and clinical studies investigating histamine-mediated pathways.

Basic Information

Product Name	Chlorcyclizine Hydrochloride
CAS No.	1620-21-9
Molecular Formula	C18H21ClN2•HCl
Molecular Weight	337.29 g/mol
Synonyms	1-(4-Chlorobenzhydryl)-4-methylpiperazine hydrochloride; Chlorcyclizine HCl; Histachlorazine; Perazil; Diparalene; Prulet; Mantadil; Chlorcyclizine Dihydrochloride; 1-(p-Chloro-α-phenylbenzyl)-4-methylpiperazine hydrochloride
EINECS	216-593-5

Quality Control

Our Chlorcyclizine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specifications for identity, purity, and impurities. We support compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.