Description

9-Fluoro-11Beta,17,21-Trihydroxy-16-Methylenepregna-1,4-Diene-3,20-Dione 21-Acetate is a high-purity synthetic steroid derivative, also known as Flumethasone 21-Acetate, which serves as a critical pharmaceutical intermediate. Its value lies in its potent glucocorticoid activity, making it a key building block for advanced corticosteroid formulations. This compound is essential for manufacturers in the pharmaceutical industry, particularly for the research and development of topical anti-inflammatory and anti-pruritic medications.

Application

• Pharmaceutical Intermediate: Primary use as a key precursor in the synthesis of the active pharmaceutical ingredient (API) Flumethasone.
• Topical Corticosteroid Production: Used in the manufacture of creams, ointments, and lotions for treating skin conditions like eczema, psoriasis, and dermatitis.
• Veterinary Medicine: A component in formulations for treating inflammatory and allergic conditions in animals.
• Research & Development: Serves as a reference standard and starting material in steroid chemistry research and new drug discovery programs.
• Anti-inflammatory Agent Synthesis: Utilized in creating specialized corticosteroids with targeted potency and reduced systemic side effects.

Basic Information

Product Name	9-Fluoro-11Beta,17,21-Trihydroxy-16-Methylenepregna-1,4-Diene-3,20-Dione 21-Acetate
CAS No.	1255-35-2
Molecular Formula	C₂₄H₂₉FO₆
Molecular Weight	432.49 g/mol
Synonyms	Flumethasone 21-Acetate; 6α,9-Difluoro-11β,17,21-trihydroxy-16-methylenepregna-1,4-diene-3,20-dione 21-acetate; NSC 107680; 16-Methylene-9α-fluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate; 9α-Fluoro-11β,17,21-trihydroxy-16-methylenepregna-1,4-diene-3,20-dione 21-acetate; 6α,9α-Difluoro-11β,17α,21-trihydroxy-16-methylenepregna-1,4-diene-3,20-dione 21-acetate; Flumetasone 21-Acetate
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,17,21-Trihydroxy-16-Methylenepregna-1,4-Diene-3,20-Dione 21-Acetate is manufactured under strict quality systems suitable for pharmaceutical intermediate use. The product undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications. Certificates of Analysis (COA) detailing batch-specific results are available upon request, supporting compliance with cGMP and relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.