Description

3-Acetyloxy-17-Hydroxy-16-Methylpregn-5-En-20-One is a high-purity steroid intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters for its role as a key building block in the production of potent corticosteroid and other steroidal APIs, where precise molecular structure is critical for biological activity. Pharmaceutical R&D laboratories and fine chemical manufacturers need it to ensure the reliability and scalability of complex synthetic pathways, directly impacting the quality and efficacy of the final drug product.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potent glucocorticoid corticosteroids and other specialized steroid-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry and process development for creating novel steroidal compounds with targeted therapeutic effects.
• Fine Chemical Synthesis: Serves as a versatile chiral building block for constructing complex molecular architectures in contract manufacturing and custom synthesis projects.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling of related steroid products.

Basic Information

Product Name	3-Acetyloxy-17-Hydroxy-16-Methylpregn-5-En-20-One
CAS No.	1249-66-7
Molecular Formula	C₂₄H₃₆O₄
Molecular Weight	388.54 g/mol
Synonyms	16α-Methylprednisolone 21-Acetate; 16α-Methyl-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 21-Acetate; 21-Acetoxy-16α-methylprednisolone; 16α-Methylprednisolone Acetate; 11β,17α,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate; 16-Methylprednisolone 21-Acetate; (11β,16α)-11,17,21-Trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-acetate
EINECS	Contact for details

Quality Control

Our 3-Acetyloxy-17-Hydroxy-16-Methylpregn-5-En-20-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.