Description

Pregna-1,4-Diene-3,11,20-Trione, 17-Hydroxy- is a high-purity steroid derivative, also known as 17-Hydroxycortexolone, which serves as a critical intermediate in the synthesis of more complex pharmaceutical compounds. Its value lies in its defined chemical structure, enabling precise and efficient downstream chemical transformations essential for research and manufacturing. This product is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of corticosteroids and other specialized steroid-based active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent corticosteroid drugs, including anti-inflammatory and immunosuppressive agents.
• Steroid Research & Development: Used as a reference standard and starting material in academic and industrial research focused on steroid hormone chemistry and metabolism.
• Fine Chemical Synthesis: Employed in custom synthesis and process development for creating novel steroid analogs with potential therapeutic applications.
• Biochemical Studies: Utilized in metabolic pathway studies to investigate the biosynthesis and degradation of steroid hormones.

Basic Information

Product Name	Pregna-1,4-Diene-3,11,20-Trione, 17-Hydroxy-
CAS No.	1242-49-5
Molecular Formula	C21H26O5
Molecular Weight	358.43 g/mol
Synonyms	17-Hydroxycortexolone; 17-Hydroxypregna-1,4-diene-3,11,20-trione; 11-Dehydro-17-hydroxycorticosterone; 17,21-Dihydroxypregn-4-ene-3,11,20-trione; Reichstein's Substance S; 11-Deoxy-17-hydroxycortisone; 17-Hydroxy-11-dehydrocorticosterone; 17α-Hydroxypregna-1,4-diene-3,11,20-trione
EINECS	214-974-5

Quality Control

Our Pregna-1,4-Diene-3,11,20-Trione, 17-Hydroxy- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.