Description

Desmethyl Doxylamine is a key pharmaceutical intermediate and metabolite of the antihistamine doxylamine. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of related active pharmaceutical ingredients (APIs). It serves as a critical building block for manufacturers and research institutions focused on developing and analyzing antihistaminic and sedative compounds.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of doxylamine succinate and related antihistamine APIs.
• Metabolite Reference Standard: Essential for analytical method development and validation in bioanalytical studies for pharmacokinetic and toxicological research.
• Research Chemical: Used in academic and industrial laboratories for pharmacological studies and structure-activity relationship (SAR) investigations.
• Impurity Standard: Serves as a certified reference material (CRM) for quality control, ensuring the purity and safety of final drug products by monitoring related substances.
• Chemical Synthesis: Acts as a precursor in organic synthesis for creating novel derivatives with potential therapeutic applications.

Basic Information

Product Name	Desmethyl Doxylamine
CAS No.	1221-70-1
Molecular Formula	C16H20N2O
Molecular Weight	256.35 g/mol
Synonyms	N,N-Dimethyl-2-[(1-phenyl-1-pyridin-2-yl)ethoxy]ethanamine; 2-[α-[2-(Dimethylamino)ethoxy]-α-methylbenzyl]pyridine; Doxylamine Impurity C; Doxylamine Related Compound C; Doxylamine Metabolite; Desmethyldoxylamine; UNII-8K7138F6JL
EINECS	Contact for details

Quality Control

Our Desmethyl Doxylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and relevant guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.