Description

21-Acetyl-6α-Chlorotriamcinolone Acetonide is a chemically modified synthetic corticosteroid derivative, primarily valued as a key intermediate in advanced pharmaceutical synthesis. Its significance lies in enabling the production of potent topical and systemic anti-inflammatory agents, offering researchers and manufacturers a critical building block for drug development. This compound is essential for pharmaceutical R&D laboratories and fine chemical producers focused on creating specialized corticosteroid medications.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel and high-potency corticosteroid drugs.
• Anti-inflammatory Drug Research: Used in the development and study of new therapeutic agents targeting inflammation, allergies, and autoimmune conditions.
• Dermatological Formulations: Serves as a key starting material for synthesizing active pharmaceutical ingredients (APIs) used in creams, ointments, and lotions.
• Steroid Chemistry & Process Development: Employed by chemists to explore new synthetic pathways and optimize manufacturing processes for steroid-based pharmaceuticals.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and impurity profiling.

Basic Information

Product Name	21-Acetyl-6α-Chlorotriamcinolone Acetonide
CAS No.	1181-32-4
Molecular Formula	C26H32ClFO7
Molecular Weight	510.98 g/mol
Synonyms	6α-Chloro-21-acetyltriamcinolone acetonide; 9α-Fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione 16,17-acetonide 6α-chloro-21-acetate; 6α-Chloro-9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone 21-acetate; Triamcinolone acetonide 6α-chloro-21-acetate derivative; 21-Acetyl-6α-chloro-9α-fluoro-11β,16α,17α-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone
EINECS	Contact for details

Quality Control

Our 21-Acetyl-6α-Chlorotriamcinolone Acetonide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. A detailed Certificate of Analysis (COA) documenting purity, related substances, and residual solvents is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.