Description

Clemizole Hydrochloride CAS NO 1163-36-6 is a potent and selective histamine H1 receptor antagonist belonging to the benzimidazole class of compounds. Its primary value lies in its utility as a key pharmaceutical intermediate and a reference standard in research and development. This compound is essential for manufacturers and research institutions focused on developing and producing antihistamine medications, as well as for pharmacological studies investigating allergic responses and receptor mechanisms.

Application

• Pharmaceutical Intermediate: Critical synthesis component for the production of antihistamine drugs.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of pharmaceutical products.
• Biochemical Research: Employed in pharmacological studies to investigate histamine H1 receptor binding, antagonism, and signal transduction pathways.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structure for the development of new therapeutic agents targeting allergic conditions.
• Veterinary Medicine: Potential application in the formulation of antihistamine treatments for animals.

Basic Information

Product Name	Clemizole Hydrochloride
CAS No.	1163-36-6
Molecular Formula	C19H21ClN2·HCl
Molecular Weight	349.30 g/mol
Synonyms	1-(4-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)benzimidazole Hydrochloride; Allercur; Histacur; NSC 113001; Pyrrobutamine Impurity B (Hydrochloride); Clemizole HCl; 1-[(4-Chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole Hydrochloride
EINECS	Contact for details

Quality Control

Our Clemizole Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates and reference standards. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for key parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; appropriate handling procedures should be followed to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.