Description

21-Di[Methylenebis(Oxy)] 5α-Dihydrocortisol is a synthetic steroid derivative, specifically a modified glucocorticoid. This compound is valued for its role as a key intermediate in advanced pharmaceutical synthesis, offering a controlled structural framework for developing novel therapeutic agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of steroidal drugs, anti-inflammatory agents, and other specialized bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the multi-step synthesis of novel corticosteroid analogs and other steroidal active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard or probe in studies investigating glucocorticoid receptor activity, metabolism, and structure-activity relationships (SAR).
• Preclinical Development: Employed in the development and testing of new drug candidates targeting inflammatory pathways, immune responses, and hormonal regulation.
• Process Chemistry: Utilized in process development and scale-up activities for the efficient and reproducible manufacturing of complex steroid-based therapeutics.

Basic Information

Product Name	21-Di[Methylenebis(Oxy)] 5α-Dihydrocortisol
CAS No.	1056-08-2
Molecular Formula	C₂₄H₃₄O₇
Molecular Weight	434.52 g/mol
Synonyms	21,21'-[Methylenebis(oxy)]bis-5α-pregnane-3,11,20-trione; 21,21'-(Methylenedioxy)bis-5α-dihydrocortisol; 5α-Dihydro-21,21-methylenedioxycortisol; 21,21-Methylenedioxy-5α-dihydrocortisol; 21,21'-Methylenebis(oxy)bis(5α-dihydrocortisol); 21,21'-O-Methylenedi-5α-dihydrocortisol; 5α-Pregnane-3,11,20-trione, 21,21'-[methylenebis(oxy)]bis-
EINECS	Contact for details

Quality Control

Our 21-Di[Methylenebis(Oxy)] 5α-Dihydrocortisol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.