Description

Buclizine, Dihydrochloride is a high-purity pharmaceutical intermediate and active ingredient. This compound is critical for ensuring the efficacy and safety of finished pharmaceutical products. It is primarily required by manufacturers in the pharmaceutical and life sciences industries for the development and production of therapeutic agents.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of antiemetic and antihistamine medications.
• Research & Development: Serves as a key reference standard and building block in pharmacological and biochemical research.
• Veterinary Medicine: Used in the development of treatments for motion sickness and allergic conditions in animals.
• Chemical Synthesis: Acts as a versatile intermediate for the synthesis of more complex chemical entities and derivatives.

Basic Information

Product Name	Buclizine, Dihydrochloride
CAS No.	129-74-8
Molecular Formula	C28H33ClN2·2HCl
Molecular Weight	505.99 g/mol
Synonyms	Buclizine HCl; Buclizine Hydrochloride; 1-(p-tert-Butylbenzyl)-4-(p-chloro-α-phenylbenzyl)piperazine Dihydrochloride; Histabutizine; Longifene; Vibazine; Buclifen; Aphilan; Postafen; Buclina
EINECS	204-949-9

Quality Control

Our Buclizine, Dihydrochloride is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency. Certificates of Analysis (COA) documenting compliance with relevant pharmacopeial standards (e.g., USP, EP) are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.