ACE Inhibitors and ARBs
Circulatory System Drugs
- Lipid Regulators
- Antianginals
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- Anticongestive Heart Failure Drugs
- Antihypertensives
- Antiarrhythmics
- Shock Vasoactive Drugs
- Other Cardiovascular Drugs
- ACE Inhibitors and ARBs
- Peripheral Vasodilators
- β-Adrenergic Receptor Blockers
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ACE Inhibitors and ARBs
ACE inhibitors and angiotensin receptor blockers (ARBs) target the renin–angiotensin–aldosterone system (RAAS) to reduce blood pressure, prevent cardiac remodeling, and protect renal function. ACE inhibitors block the conversion of angiotensin I to angiotensin II, while ARBs selectively block angiotensin II receptors. Both classes reduce vasoconstriction, aldosterone secretion, and sympathetic activation. They are widely used in hypertension, heart failure, diabetic nephropathy, and post-myocardial infarction recovery. Clinical benefits include improved survival, reduced hospitalizations, and delayed progression of kidney damage. Adverse effects may include hyperkalemia, cough (ACEIs), hypotension, or renal impairment. These drugs remain foundational in cardiovascular and renal disease management.
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