Description

5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-8-(1-oxopropyl)-, (8S-cis)- (9CI) is a complex, high-purity anthracycline derivative of significant interest in advanced pharmaceutical research and development. Its intricate molecular structure, featuring a glycosylated naphthacenedione core, makes it a critical building block for the synthesis of novel therapeutic agents, particularly in oncology. This compound is essential for research chemists and process development scientists working in pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality intermediates for drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of novel anthracycline-based chemotherapeutic agents.
• Biochemical Research: Used in studies investigating structure-activity relationships (SAR) of DNA-intercalating compounds and topoisomerase inhibitors.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Process Chemistry: Utilized in route scouting and optimization for the scalable synthesis of complex active pharmaceutical ingredients (APIs).
• Academic Research: A valuable compound for universities and research institutes studying organic synthesis methodologies and medicinal chemistry.

Basic Information

Product Name	5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-8-(1-oxopropyl)-, (8S-cis)- (9CI)
CAS No.	771423-67-7
Molecular Formula	C27H33NO11
Molecular Weight	547.55 g/mol
Synonyms	10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-8-(1-oxopropyl)-5,12-naphthacenedione; (8S-cis)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-8-propionyl-5,12-naphthacenedione; 8S-cis Isomer of a glycosylated anthracycline derivative; Complex anthracycline glycoside intermediate; Amino-deoxyglycosyl naphthacenedione.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specification results is provided with each shipment. We support cGMP-compliant documentation for pharmaceutical development projects upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange-red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Single Maximum Impurity	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.