Description

Minocycline Hydrochloride is a semi-synthetic, broad-spectrum tetracycline antibiotic derived from oxytetracycline. It is valued for its potent antibacterial activity against a wide range of Gram-positive and Gram-negative organisms, including those resistant to other tetracyclines. This makes it a critical active pharmaceutical ingredient (API) for manufacturers in the pharmaceutical and veterinary medicine industries, particularly for formulating oral and topical medications.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in human antibiotic formulations (capsules, tablets).
• Key component in veterinary pharmaceuticals for treating bacterial infections in livestock and companion animals.
• Utilized in topical preparations such as creams, ointments, and gels for skin infections like acne vulgaris.
• Research and development of novel drug delivery systems to enhance bioavailability and efficacy.
• Intermediate in the synthesis of more complex pharmaceutical compounds and derivatives.
• Reference standard in analytical laboratories for quality control and method validation.

Basic Information

Product Name	Minocycline Hydrochloride
CAS No.	13614-98-7
Molecular Formula	C₂₃H₂₇N₃O₇ • HCl
Molecular Weight	493.94 g/mol
Synonyms	Minocycline HCl; 7-Dimethylamino-6-deoxy-6-demethyltetracycline hydrochloride; Minocin (brand name); Minocyclinum hydrochloridum; U-32059; Minocycline monohydrochloride; 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
EINECS	237-115-6

Quality Control

Our Minocycline Hydrochloride is manufactured and tested to meet stringent pharmacopeial standards, including USP and EP monographs. Every batch undergoes comprehensive analytical testing to ensure identity, purity, potency, and the absence of harmful impurities. A detailed Certificate of Analysis (COA), documenting results for assay, related substances, residual solvents, and microbiological quality, is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
pH (1% Solution)	3.5 - 5.0
Water (KF Titration)	≤ 6.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Specific Rotation	-160° to -173°
Microbiological Enumeration	Complies with EP/USP

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.