Description

Demeclocycline CAS NO 127-33-3 is a broad-spectrum tetracycline-class antibiotic derived from a strain of *Streptomyces aureofaciens*. This compound is valued for its bacteriostatic activity against a wide range of Gram-positive and Gram-negative organisms. It is primarily utilized in pharmaceutical research and development, serving as a critical reference standard and active pharmaceutical ingredient (API). Key industries requiring this material include pharmaceutical manufacturing, academic research, and analytical laboratories.

Application

• Pharmaceutical Active Ingredient (API) for antibiotic formulations.
• Research and Development (R&D) of novel antimicrobial agents.
• Microbiological research as a reference standard for susceptibility testing.
• Manufacturing of veterinary medicinal products.
• Analytical chemistry as a high-purity certified reference material (CRM).
• Biochemical studies investigating protein synthesis inhibition.

Basic Information

Product Name	Demeclocycline
CAS No.	127-33-3
Molecular Formula	C21H21ClN2O8
Molecular Weight	464.86 g/mol
Synonyms	Demethylchlortetracycline; 7-Chloro-6-demethyltetracycline; Declomycin; Ledermycin; Demeclocycline Hydrochloride; DMCT; 6-Demethyl-7-chlorotetracycline; Clortetrin
EINECS	204-843-8

Quality Control

Our Demeclocycline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research. We provide full traceability and Certificates of Analysis (COA) upon request, detailing parameters such as assay, purity, and identification. Specifications can align with in-house pharmacopeial standards (e.g., USP, EP) for API-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	Yellow to Yellowish-brown, Crystalline Powder
Identification (IR)	Conforms to Standard
Identification (HPLC)	Retention time corresponds to Reference Standard
Assay (HPLC)	≥ 98.0 %
Water Content (KF)	≤ 2.0 %
Residue on Ignition	≤ 0.5 %
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total Impurities ≤ 2.0%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.