Description

4-Amino-7-Chloro-1,4,4A,5,12,12A-Hexahydro-3,10,11,12A-Tetrahydroxy-1,12-Dioxo-2-Naphthacenecarboxamide is a complex tetracycline-class intermediate of significant importance in pharmaceutical synthesis. This compound matters for its role as a key precursor in the production of advanced antibiotic and therapeutic agents, where high purity and structural integrity are critical. It is primarily needed by research institutions and manufacturers in the pharmaceutical and biotechnology industries engaged in the development of novel anti-infective drugs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of semi-synthetic tetracycline antibiotics.
• Active Pharmaceutical Ingredient (API) Development: Used in research and development for new antibacterial compounds targeting resistant pathogens.
• Biochemical Research: Serves as a reference standard or substrate in studies of antibiotic mechanism of action and bacterial protein synthesis inhibition.
• Veterinary Medicine Synthesis: Employed in the production of broad-spectrum antibiotics for animal health applications.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	4-Amino-7-Chloro-1,4,4A,5,12,12A-Hexahydro-3,10,11,12A-Tetrahydroxy-1,12-Dioxo-2-Naphthacenecarboxamide
CAS No.	13977-41-8
Molecular Formula	C₂₁H₂₀ClN₃O₈
Molecular Weight	477.85 g/mol
Synonyms	7-Chloro-4-amino-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-1,12-dioxo-2-naphthacenecarboxamide; 4-Amino-7-chloro-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-1,12-dioxo-2-naphthacenecarboxamide; 4-Amino-7-chloro-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-1,12-dioxonaphthacene-2-carboxamide; Tetracycline derivative intermediate; 4-Amino-7-chloro-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-1,12-dioxo-2-naphthacenecarboxamide (CAS 13977-41-8)
EINECS	Contact for details

Quality Control

Our 4-Amino-7-Chloro-1,4,4A,5,12,12A-Hexahydro-3,10,11,12A-Tetrahydroxy-1,12-Dioxo-2-Naphthacenecarboxamide is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing batch-specific results are available upon request, supporting compliance with cGMP and relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.