Description

Minocycline CAS NO 10118-90-8 is a broad-spectrum, semi-synthetic tetracycline antibiotic derived from oxytetracycline. It is valued for its potent antibacterial activity against a wide range of Gram-positive and Gram-negative organisms, including those resistant to other tetracyclines. This compound is a critical active pharmaceutical ingredient (API) primarily demanded by the pharmaceutical industry for the formulation of oral and topical medications.

Application

• Pharmaceutical API: Primary use as the active ingredient in oral capsules, tablets, and topical formulations for treating bacterial infections.
• Acne Treatment: Key component in long-term dermatological therapies for moderate to severe acne vulgaris.
• Rosacea Management: Used in anti-inflammatory treatments for managing symptoms of rosacea.
• Respiratory Infections: Formulated in medications targeting bronchitis, pneumonia, and other respiratory tract infections.
• Urinary Tract Infections (UTIs): Employed in treatments for certain types of UTIs.
• Research & Development: Serves as a reference standard and biochemical tool in microbiological and pharmacological research.
• Veterinary Medicine: Used in certain veterinary antibiotic preparations.

Basic Information

Product Name	Minocycline
CAS No.	10118-90-8
Molecular Formula	C23H27N3O7
Molecular Weight	457.48 g/mol
Synonyms	Minocycline; Minocycline Base; 7-Dimethylamino-6-demethyl-6-deoxytetracycline; Minocin; Minomycin; Klinomycin; Mynocine; Minocycline Hydrochloride (when referring to the salt form); Minocycline (USP)
EINECS	233-334-8

Quality Control

Our Minocycline is manufactured under strict quality management systems. It is typically tested to meet or exceed relevant pharmacopeial standards such as USP (United States Pharmacopeia) and EP (European Pharmacopoeia). Each batch undergoes rigorous analytical testing including identification, assay, impurity profiling, and residual solvent analysis. Certificates of Analysis (COA) documenting full compliance with specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (Karl Fischer)	≤ 6.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Specific Optical Rotation	-160° to -175° (c=1, in 0.1N HCl)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.