Description

[(6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-acetyloxyacetyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate is a high-purity synthetic steroid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of novel glucocorticoid receptor modulators and other potent therapeutic agents. It is essential for pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug discovery programs targeting inflammatory and autoimmune diseases.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel fluorinated corticosteroid analogs with enhanced potency and selectivity.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies to develop new anti-inflammatory and immunosuppressive agents.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis (HPLC, LC-MS).
• Biochemical Research: Tool compound for investigating glucocorticoid receptor (GR) signaling pathways and mechanisms of action in cellular and molecular biology.
• Process Chemistry Development: Used in scaling up and optimizing synthetic routes for the commercial production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	[(6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-acetyloxyacetyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
CAS No.	79861-38-4
Molecular Formula	C₂₇H₃₄F₂O₇
Molecular Weight	508.55 g/mol
Synonyms	6α,9α-Difluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17,21-diacetate; Difluoroprednisolone 17,21-diacetate; 6α,9α-Difluoroprednisolone 17,21-diacetate; Fluorometholone related compound; 17,21-Diacetoxy-6α,9α-difluoro-11β-hydroxy-16α-methylpregna-1,4-diene-3,20-dione; 6α,9α-Difluoro-11β-hydroxy-16α-methyl-17α,21-bis(acetyloxy)pregna-1,4-diene-3,20-dione
EINECS	Contact for details

Quality Control

Our [(6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-acetyloxyacetyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications and test results (including HPLC purity, chiral purity, and residual solvents) are provided and available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (by Chiral HPLC)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.