Description

S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 3-oxododecanethioate is a sophisticated, high-purity biochemical intermediate designed for advanced research and pharmaceutical development. This compound matters for its role as a key building block in the synthesis of nucleotide-based prodrugs and targeted therapeutic agents, offering precise control over drug delivery and activation. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on antiviral therapies, oncology, and metabolic disease research.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of nucleotide prodrugs, particularly in antiviral and anticancer therapeutic development.
• Bioconjugation Research: Used in the development of targeted drug delivery systems due to its reactive thioate and ketone functional groups for site-specific conjugation.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a component in the linker or warhead design for novel protein degradation therapeutics.
• Metabolic Pathway Studies: Employed as a tool compound to investigate nucleotide salvage pathways and related enzymatic processes.
• Labeled Compound Synthesis: A precursor for creating isotopically labeled (e.g., 13C, 15N, 2H) analogs for pharmacokinetic and metabolic tracing studies.
• Enzyme Substrate Analog: Acts as a substrate or inhibitor analog for enzymes involved in nucleotide metabolism and signaling.

Basic Information

Product Name	S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 3-oxododecanethioate
CAS No.	78303-19-2
Molecular Formula	C₃₃H₅₄N₇O₁₇P₃S
Molecular Weight	977.81 g/mol
Synonyms	3-Oxododecanoic acid S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] ester; Adenosine 5'-(tetrahydrogen triphosphate), 5'→5'-ester with 3,3-dimethyl-4-[[3-[[2-[(3-oxododecanoyl)thio]ethyl]amino]-3-oxopropyl]amino]-2-hydroxy-4-oxobutanoic acid; Nucleotide-Lipid Conjugate; Acylated Nucleotide Thioester; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 3-oxododecanethioate is manufactured under strict quality systems suitable for research and development use. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and reliability. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, containers should be sealed under an inert atmosphere (e.g., nitrogen or argon) after opening and allowed to equilibrate to room temperature before use to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.