Description

Cocarboxylase CAS NO 154-87-0 is the diphosphate ester of thiamine (vitamin B1), functioning as a critical coenzyme in cellular energy metabolism. Its primary commercial value lies in its essential role as a cofactor for key enzymes like pyruvate dehydrogenase and transketolase, facilitating carbohydrate metabolism and energy production. This makes it a vital ingredient for manufacturers in the pharmaceutical, nutraceutical, and research sectors, particularly for formulating metabolic support products, cell culture media, and biochemical research reagents.

Application

• Pharmaceutical Formulations: Used as an active pharmaceutical ingredient (API) or excipient in injectable and oral preparations for treating thiamine deficiency and related metabolic disorders.
• Nutraceuticals & Dietary Supplements: Incorporated into high-end vitamin B-complex supplements and energy metabolism support products for enhanced bioavailability.
• Biochemical Research & Diagnostics: Serves as an essential cofactor in enzyme assays, metabolic pathway studies, and diagnostic kits requiring pyruvate dehydrogenase activity.
• Cell Culture & Fermentation Media: Added as a key growth factor in specialized media for mammalian cell culture, microbial fermentation, and bioprocessing applications.
• Veterinary Medicine: Employed in metabolic treatments and nutritional supplements for livestock and companion animals.
• Cosmeceuticals: Utilized in advanced skincare formulations targeting cellular energy and revitalization due to its role in fundamental metabolic processes.

Basic Information

Product Name	Cocarboxylase
CAS No.	154-87-0
Molecular Formula	C12H19ClN4O7P2S
Molecular Weight	460.76 g/mol
Synonyms	Thiamine Pyrophosphate Chloride; TPP; Thiamine Diphosphate Chloride; Cocarboxylase Chloride; Vitamin B1 Pyrophosphate; Thiamin Pyrophosphate Chloride; Co-carboxylase; Diphosphothiamine
EINECS	205-836-5

Quality Control

Our Cocarboxylase is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets high-purity standards suitable for pharmaceutical and research applications. Certificates of Analysis (COA) documenting full specifications are available upon request, and production can be aligned with current Good Manufacturing Practice (cGMP) principles for regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
pH (1% Solution)	2.0 - 3.5
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.