Description

Methyl (1R,2R,4S)-4-[(2S,4S,5S,6S)-4-dimethylamino-5-[(2S,4S,5R,6S)-4- hydroxy-6-methyl-5-[(2S,6S)-6-methyl-5-oxo-oxan-2-yl]oxy-oxan-2-yl]oxy -6-methyl-oxan-2-yl]oxy-2-ethyl-2,5,12-trihydroxy-6,11-dioxo-3,4-dihyd ro-1H-tetracene-1-carboxylate is a complex, stereochemically defined chemical intermediate of significant importance in advanced pharmaceutical synthesis. This compound serves as a critical building block for the development of novel therapeutic agents, particularly in the field of oncology. It is primarily sought after by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of sophisticated active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of novel anthracycline and tetracycline-derived antibiotic and anticancer agents.
• Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• API Synthesis: Employed in the production of complex, high-value active pharmaceutical ingredients (APIs) requiring precise stereochemical control.
• Biochemical Research: Utilized as a tool compound in biochemical assays to study mechanisms of action involving DNA intercalation and topoisomerase inhibition.
• Process Chemistry: Serves as a benchmark or reference standard for the development and optimization of scalable synthetic routes in process chemistry.

Basic Information

Item	Details
Product Name	Methyl (1R,2R,4S)-4-[(2S,4S,5S,6S)-4-dimethylamino-5-[(2S,4S,5R,6S)-4- hydroxy-6-methyl-5-[(2S,6S)-6-methyl-5-oxo-oxan-2-yl]oxy-oxan-2-yl]oxy -6-methyl-oxan-2-yl]oxy-2-ethyl-2,5,12-trihydroxy-6,11-dioxo-3,4-dihyd ro-1H-tetracene-1-carboxylate
CAS No.	76463-92-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Methyl 4-O-(4-Dimethylamino-5-O-(4-hydroxy-6-methyl-5-O-(6-methyl-5-oxo-2H-pyran-2-yl)-2H-pyran-2-yl)-6-methyl-2H-pyran-2-yl)-2-ethyl-2,5,12-trihydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate; Aclacinomycin A methyl ester; Aclarubicin methyl ester; (1R,2R,4S)-Methyl 2-ethyl-2,5,12-trihydroxy-4-[(2S,4S,5S,6S)-5-[(2S,4S,5R,6S)-5-[(2S,6S)-6-methyl-5-oxo-2H-pyran-2-yl]oxy-4-hydroxy-6-methyl-2H-pyran-2-yl]oxy-4-(dimethylamino)-6-methyl-2H-pyran-2-yl]oxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate; Antibiotic MA 144 M1; MA 144 M1
EINECS	Contact for details

Quality Control

Our methyl (1R,2R,4S)-4-[(2S,4S,5S,6S)-4-dimethylamino-5-[(2S,4S,5R,6S)-4- hydroxy-6-methyl-5-[(2S,6S)-6-methyl-5-oxo-oxan-2-yl]oxy-oxan-2-yl]oxy -6-methyl-oxan-2-yl]oxy-2-ethyl-2,5,12-trihydroxy-6,11-dioxo-3,4-dihyd ro-1H-tetracene-1-carboxylate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and impurity profile analysis, to ensure it meets the exacting standards required for pharmaceutical R&D and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.