Description

[2S-[2alpha(8R*,10R*),4beta,6beta]]-10-[(4-aminotetrahydro-6-methyl-2H-pyran-2-yl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride is a complex, high-purity pharmaceutical intermediate and reference standard. This compound matters for its critical role in the synthesis and analytical validation of advanced pharmaceutical agents, particularly within the anthracycline class. It is essential for research institutions, pharmaceutical manufacturers, and quality control laboratories engaged in the development and production of specialized therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex anthracycline-based active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Used for method development, validation, and quality control testing (e.g., HPLC, LC-MS) in pharmaceutical analysis.
• Biochemical Research: Serves as a precise chemical tool for studying structure-activity relationships (SAR) and mechanism of action in oncology research.
• GMP Manufacturing: Employed in controlled, Good Manufacturing Practice (GMP) environments for the production of clinical trial materials and commercial drugs.
• Impurity Profiling: Acts as a characterized impurity or degradation product standard to ensure drug substance purity and regulatory compliance.

Basic Information

Product Name	[2S-[2alpha(8R*,10R*),4beta,6beta]]-10-[(4-aminotetrahydro-6-methyl-2H-pyran-2-yl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride
CAS No.	63950-06-1
Molecular Formula	C28H32ClNO12
Molecular Weight	610.01 g/mol
Synonyms	Doxorubicin Hydrochloride Related Compound; 10-[(4-Amino-2,3,4,6-tetradeoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione Hydrochloride; Adriamycin Related Compound; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione Hydrochloride; Doxorubicin HCl Impurity; Anthracycline Intermediate
EINECS	Contact for details

Quality Control

Our [2S-[2alpha(8R*,10R*),4beta,6beta]]-10-[(4-aminotetrahydro-6-methyl-2H-pyran-2-yl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity, identity confirmation (IR, NMR), and residual solvent analysis, to ensure it meets exacting standards for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. Due to its hygroscopic nature, the container must be kept in a dry environment and sealed immediately after use to prevent moisture absorption.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Assay (on dried basis)	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.