Description

4-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylsulfanylcarbonyl]but-3-enoic acid is a complex, high-purity biochemical intermediate of significant interest in advanced pharmaceutical research and development. Its intricate molecular structure, featuring a modified nucleotide core linked to a reactive thioester, makes it a critical building block for targeted drug discovery, particularly in areas like prodrug synthesis and enzyme inhibition. This compound is essential for researchers and manufacturers in the biopharmaceutical, life sciences, and fine chemical sectors who require specialized, high-quality intermediates for developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel nucleotide-based prodrugs and active pharmaceutical ingredients (APIs).
• Bioconjugation & Prodrug Development: Utilized for creating targeted drug delivery systems via its reactive thioester and carboxylic acid functional groups.
• Enzyme Inhibitor Research: Acts as a substrate analog or inhibitor in biochemical studies targeting specific kinases and transferases.
• Antiviral & Anticancer Agent Synthesis: Employed in the research and development of nucleotide analogs with potential therapeutic activity.
• Biochemical Probe Development: Used to create labeled or modified probes for studying cellular processes and signal transduction pathways.
• Peptide & Protein Modification: Facilitates site-specific modifications of biomolecules for enhanced stability or functionality.

Basic Information

Product Name	4-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylsulfanylcarbonyl]but-3-enoic acid
CAS No.	6712-05-6
Molecular Formula	C27H41N7O18P3S
Molecular Weight	876.70 g/mol
Synonyms	ATP-ribosyl cyclase/ADP-ribosyl cyclase inhibitor; 3'-Deoxy-3'-(4-morpholinyl)doxorubicin; 3'-Deoxy-3'-morpholinodoxorubicin; 3'-De-oxy-3'-morpholino-13-deoxo-10-hydroxycarminomycin; PNU-107859; 3'-Deoxy-3'-morpholino-13-deoxo-10-hydroxycarminomycin; 4-[2-[3-[[4-[[[5-(6-Aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylsulfanylcarbonyl]but-3-enoic acid
EINECS	Contact for details

Quality Control

Our production of this high-value biochemical adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, supporting your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, containers should be allowed to equilibrate to room temperature before opening to minimize moisture ingress. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.