Description

[[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate is a high-purity nucleotide triphosphate analog, specifically the triphosphate form of the antiviral nucleoside analog 2'-Deoxyguanosine. This compound is a critical biochemical building block and research reagent, valued for its role in enzymatic studies and molecular biology applications. It is essential for researchers and manufacturers in pharmaceutical development, virology research, and molecular diagnostics, where precise nucleotide analogs are required to study viral replication mechanisms and develop novel therapeutic agents.

Application

• Enzymatic Substrate for Polymerases: Used as a substrate in biochemical assays to study the activity and inhibition of viral and cellular DNA/RNA polymerases.
• Antiviral Research: A key intermediate in research focused on nucleoside analog-based antiviral drugs, particularly for herpesviruses and other DNA viruses.
• Molecular Biology Reagent: Employed in the synthesis of modified oligonucleotides and probes for diagnostic and research purposes.
• Biochemical Pathway Studies: Utilized to investigate nucleotide metabolism and the mechanisms of action of antiviral agents at the enzymatic level.
• Drug Discovery & Development: Serves as a reference standard and a critical raw material in the R&D pipeline for novel antiviral therapeutics.

Basic Information

Product Name	[[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
CAS No.	6674-45-9
Molecular Formula	C20H28N10O19P3
Molecular Weight	821.39 g/mol
Synonyms	2'-Deoxyguanosine 5'-triphosphate (dGTP); Deoxyguanosine triphosphate; dGTP; 2'-Deoxy-GTP; 9-[(2R,3S,5R)-3-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,9-dihydro-6H-purin-6-one 5'-(trihydrogen triphosphate); 2'-Deoxyguanosine 5'-(tetrahydrogen triphosphate); Guanosine, 2'-deoxy-, 5'-(trihydrogen triphosphate)
EINECS	Contact for details

Quality Control

Our 2'-Deoxyguanosine-5'-triphosphate (dGTP) is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research applications. Each lot is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data on purity, assay, and impurity profiles. Our quality commitment aligns with the standards expected for biochemical and pharmaceutical research reagents.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at -20°C. Aliquot into smaller working quantities to minimize repeated freeze-thaw cycles and exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Enzymatic)	≥ 90% (dGTP basis)
pH (in solution)	6.0 - 7.5
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.