Description

2-[2-[3-[[4-[[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylsulfanylcarbonylmethyl]prop-2-enoic acid is a sophisticated, high-purity biochemical building block designed for advanced research and development. This compound is critical for applications requiring precise molecular conjugation, particularly in the development of targeted therapeutic agents and diagnostic probes. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on nucleotide-based drug discovery, prodrug synthesis, and bioconjugation strategies.

Application

• Bioconjugation Reagent: For the site-specific attachment of therapeutic payloads, such as cytotoxic drugs or imaging agents, to antibodies, proteins, or peptides.
• Nucleotide Prodrug Development: As a key intermediate in the synthesis of prodrugs designed to improve the bioavailability and targeted delivery of nucleotide analogs.
• Antibody-Drug Conjugate (ADC) Linker-Payload Synthesis: Enables the creation of novel, cleavable linker systems for next-generation ADCs.
• Diagnostic Probe Synthesis: Used in the development of fluorescent or radioactive probes for molecular imaging and diagnostic assays.
• Polymerase Chain Reaction (PCR) Probe Modification: For the custom synthesis of modified primers and probes with specialized functional groups.
• Biomaterial Functionalization: To introduce reactive groups onto surfaces or polymers for biosensor and tissue engineering applications.
• Chemical Biology Research: As a tool compound for studying enzyme mechanisms, nucleic acid interactions, and cellular signaling pathways.

Basic Information

Product Name	2-[2-[3-[[4-[[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylsulfanylcarbonylmethyl]prop-2-enoic acid
CAS No.	6008-93-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	6-Amino-9-[(2R,3R,4R,5R)-5-[[[[[[3-[[2-[(2-Carboxyethyl)thio]-1-oxoethyl]amino]-2-hydroxy-2-methyl-1-oxobutyl]amino]acetyl]amino]methyl]-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl]oxyphosphoryl]-1H-purine; Adenosine 5'-(tetrahydrogen triphosphate), 2'-deoxy-, P'-→5'-ester with N-[3-[[2-[(2-carboxyethyl)thio]-1-oxoethyl]amino]-2-hydroxy-2-methyl-1-oxobutyl]glycine; A modified nucleotide-acyl carrier protein conjugate; Custom bioconjugation linker; dATP-based reactive ester.
EINECS	Contact for details

Quality Control

Every batch of this high-value biochemical is produced and tested under strict quality management systems to ensure identity, purity, and consistency. Our analytical protocols employ advanced techniques including HPLC, LC-MS, and NMR to verify structural integrity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 90.0% (by weight)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.