Description

2-Naphthacenecarboxamide, 11a-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,11a,12,12a-decahydro-3,5,10,12a-tetrahydroxy-6-methylene-1,11,12-trioxo-, [4S-(4alpha,4aalpha,5alpha,5aalpha,11aalpha,12aalpha)]-, mono(4-methylbenzenesulfonate) (salt) is a complex tetracycline derivative salt, specifically formulated to enhance stability and handling properties. This compound is valued for its role as a critical pharmaceutical intermediate in the synthesis of advanced antibiotic agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of novel therapeutic compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of semi-synthetic tetracycline-class antibiotics.
• Biomedical Research: Used in biochemical and microbiological research to study antibiotic mechanisms of action and resistance.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Active Pharmaceutical Ingredient (API) Development: Employed in the R&D of new antibacterial drug candidates targeting a broad spectrum of pathogens.
• Chemical Synthesis: Utilized in organic synthesis for the preparation of structurally modified tetracycline analogs with potentially improved properties.

Basic Information

Item	Details
Product Name	2-Naphthacenecarboxamide, 11a-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,11a,12,12a-decahydro-3,5,10,12a-tetrahydroxy-6-methylene-1,11,12-trioxo-, [4S-(4alpha,4aalpha,5alpha,5aalpha,11aalpha,12aalpha)]-, mono(4-methylbenzenesulfonate) (salt)
CAS No.	54046-89-8
Molecular Formula	C₂₈H₃₁ClN₂O₁₁S
Molecular Weight	639.07 g/mol
Synonyms	11a-Chloro-6-methylene-4-(dimethylamino)-1,4,4a,5,5a,6,11,11a,12,12a-decahydro-3,5,10,12a-tetrahydroxy-1,11,12-trioxo-2-naphthacenecarboxamide p-toluenesulfonate salt; 6-Methylene-11a-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,11a,12,12a-decahydro-3,5,10,12a-tetrahydroxy-1,11,12-trioxo-2-naphthacenecarboxamide 4-methylbenzenesulfonate; Tetracycline derivative p-toluenesulfonate salt; 6-Methyleneoxytetracycline p-toluenesulfonate; Methacycline p-toluenesulfonate salt (related derivative); Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our production of this pharmaceutical-grade intermediate adheres to stringent quality protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and impurity profiling, to ensure it meets exacting specifications for research and synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, assay, and impurity limits to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Long-term storage under inert atmosphere is recommended.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.