Description

[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate is a high-purity nucleotide derivative, serving as a critical building block for advanced biochemical research and pharmaceutical development. Its primary value lies in its role as a precursor for synthesizing complex nucleotide analogs and as a key intermediate in the study of cellular energy metabolism and signaling pathways. This compound is essential for researchers and manufacturers in the biotechnology, pharmaceutical, and diagnostic sectors who require high-fidelity nucleotide components for drug discovery, molecular biology, and enzymatic studies.

Application

• Pharmaceutical Intermediate: A key starting material for the synthesis of novel antiviral and anticancer nucleotide analog drugs.
• Biochemical Research: Used in enzymatic studies, particularly those involving kinases, ATP-dependent processes, and energy transfer mechanisms.
• Diagnostic Reagent Manufacturing: Serves as a critical component in the production of high-sensitivity assay kits for cellular metabolism and disease biomarkers.
• Nucleotide Chemistry: An essential substrate for chemists developing modified oligonucleotides and exploring novel phosphorylation pathways.
• Cell Culture & Metabolism Studies: Applied in research to modulate or trace ATP-related metabolic pathways in cell-based assays.
• Enzyme Cofactor Synthesis: Used in the preparation of specialized cofactors and labeled nucleotides for proteomics and genomics research.

Basic Information

Product Name	[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
CAS No.	5542-28-9
Molecular Formula	C20H30N10O22P4
Molecular Weight	904.41 g/mol
Synonyms	Adenosine 5'-(tetrahydrogen triphosphate), 5'-ester with adenosine 5'-(dihydrogen phosphate); P1,P4-Bis(5'-adenosyl) tetraphosphate; Ap4A; Diadenosine tetraphosphate; Adenosine(5')tetraphospho(5')adenosine; Adenosine 5',5'''-P1,P4-tetraphosphate; Diadenosine 5',5'''-P1,P4-tetraphosphate; Bis(adenosine)-5'-tetraphosphate
EINECS	226-886-1

Quality Control

Our Diadenosine tetraphosphate (Ap4A) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles. We support compliance with relevant pharmacopeial guidelines and can tailor specifications to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at low temperature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 90.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, buffer solutions
Biological Activity	Tested in standard enzymatic assay (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.