Description

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, [4S-(4alpha,4aalpha,5alpha,5aalpha,6beta,12aalpha)]- is a complex, stereochemically defined tetracycline derivative supplied as a monohydrochloride salt. This compound is of significant value as a key intermediate or reference standard in advanced pharmaceutical research and development. It is primarily required by pharmaceutical manufacturers, biotechnology companies, and contract research organizations (CROs) engaged in the synthesis and study of novel antibiotic agents.

Application

• Pharmaceutical Intermediate: Critical starting material or building block in the multi-step synthesis of novel tetracycline-class antibiotics.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) testing in pharmaceutical manufacturing.
• Biochemical Research: Serves as a tool compound for studying antibiotic mechanisms of action, bacterial resistance, and structure-activity relationships (SAR).
• Active Pharmaceutical Ingredient (API) Development: Investigated for potential use in the development of new antibacterial therapies targeting resistant pathogens.
• Process Chemistry: Utilized in scaling up synthetic routes and optimizing production processes for complex molecules.

Basic Information

Product Name	2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, [4S-(4alpha,4aalpha,5alpha,5aalpha,6beta,12aalpha)]-
CAS No.	41411-66-9
Molecular Formula	C23H29ClN2O9
Molecular Weight	512.94 g/mol
Synonyms	4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride; (4S,4aS,5aR,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide hydrochloride; 6-Deoxy-6-demethyl-6-methylene-5-oxytetracycline hydrochloride; Sancycline hydrochloride; 6-Demethyl-6-deoxytetracycline hydrochloride; A related tetracycline derivative hydrochloride salt.
EINECS	Contact for details

Quality Control

Our high-purity pharmaceutical intermediate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets exacting specifications for research and development use. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Long-term storage under inert atmosphere is recommended.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Assay (Anhydrous Basis)	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.