Description

[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-[hydroxy-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-phosphoryl]oxy-phosphinic acid is a high-purity nucleotide derivative, also known as Uridine 5'-diphosphoglucose disodium salt. This compound is a critical biochemical reagent, serving as an essential glycosyl donor in enzymatic synthesis and metabolic pathways. It is indispensable for research and production in pharmaceutical development, enzymology, and carbohydrate chemistry, where precise biological activity and structural integrity are paramount.

Application

• Enzymatic Glycosylation Reactions: As a key substrate (UDP-glucose) for glycosyltransferases in the synthesis of oligosaccharides, glycoproteins, and natural products.
• Biochemical Research: Used in studies of carbohydrate metabolism, cell signaling, and glycobiology to understand disease mechanisms and cellular processes.
• Pharmaceutical Intermediate: Serves as a building block in the development of novel therapeutics, including antiviral agents and metabolic modulators.
• Diagnostic Kit Manufacturing: Employed as a critical component in enzymatic assay kits for clinical diagnostics and research.
• Biocatalyst Development: Utilized in enzyme screening and engineering for industrial biocatalysis applications.
• Reference Standard: Acts as a high-purity analytical standard for quality control in pharmaceutical and life science industries.

Basic Information

Item	Details
Product Name	[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-[hydroxy-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-phosphoryl]oxy-phosphinic acid
CAS No.	4220-91-1
Molecular Formula	C15H24N2O17P2
Molecular Weight	566.30 g/mol
Synonyms	UDP-glucose; Uridine 5'-diphosphoglucose; Uridine diphosphate glucose; UDP-D-glucose; UDPG; Uridine 5'-pyrophosphate glucose; 1-UDP-glucose; Uridine diphosphoglucose; Uridine 5'-diphospho-α-D-glucose
EINECS	224-168-2

Quality Control

Our nucleotide derivatives are produced under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS. We provide full traceability and Certificates of Analysis (COA) detailing assay, impurity profiles, and microbiological data where applicable, ensuring compliance with research and cGMP-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
pH (1% Solution)	6.0 - 8.0
Biological Activity (Enzymatic)	≥ 95% of theoretical
Endotoxin (LAL)	< 0.1 EU/mg (if required)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.