Description

S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 3-hydroxy-2-methylpropanethioate is a sophisticated nucleotide analog derivative, representing a key intermediate in advanced pharmaceutical research and development. Its complex structure is engineered to modulate specific biochemical pathways, making it a critical component for synthesizing novel therapeutic agents. This high-purity compound is primarily sought by research institutions and pharmaceutical companies focused on antiviral, anticancer, and metabolic disorder drug discovery.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel nucleotide-based therapeutics targeting viral infections and specific cancers.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleotide metabolism and related cellular processes.
• Prodrug Development: Serves as a precursor molecule in the design of prodrugs aimed at improving drug delivery, bioavailability, and targeting.
• Antiviral Agent Synthesis: A key starting material in the research and development pipeline for next-generation antiviral medications.
• Labeled Compound Synthesis: Can be used to create isotopically labeled versions (e.g., with C-13, N-15) for pharmacokinetic and metabolic tracing studies.
• High-Value Fine Chemical: Supplied to contract research organizations (CROs) and custom synthesis laboratories for specialized client projects.

Basic Information

Product Name	S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 3-hydroxy-2-methylpropanethioate
CAS No.	319440-43-2
Molecular Formula	C24H40N7O16P3S
Molecular Weight	831.59 g/mol
Synonyms	9-[(2-Phosphonomethoxy)ethyl]adenine bis(POM) prodrug intermediate; PMEA bis(POM) intermediate; Adefovir dipivoxil analog intermediate; Bis(POC) PMEA; Tenofovir prodrug related compound; Nucleotide phosphonate prodrug; [[(2R)-2-[[(2S)-2-[[2-[[2-(2-Hydroxy-2-methylpropoxy)-1-oxoethyl]thio]ethyl]amino]-2-oxoethyl]amino]-3,3-dimethyl-1-oxobutoxy]methoxyphosphinyl] methyl (2S)-2-(6-amino-9H-purin-9-yl)-4-hydroxy-5-(hydroxyphosphinatooxy)oxolane-3-carboxylate; GS 7340 precursor
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and purity suitable for research and development. Production adheres to cGMP (current Good Manufacturing Practice) guidelines where applicable. Identity, purity, and impurity profiles are verified using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Single Unknown Impurity	≤ 1.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.