Description

11a-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,11a,12,12a-decahydro-3,5,10,12a-tetrahydroxy-6-methylene-1,11,12-trioxonaphthacene-2-carboxamide mono(toluene-p-sulphonate) is a high-purity chemical intermediate with a complex tetracyclic structure. This compound is valued for its role as a key building block in the synthesis of advanced pharmaceutical agents, particularly in the development of novel antibiotics and anti-cancer therapeutics. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of next-generation treatments, where precise molecular structure and high purity are critical for efficacy and safety.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel tetracycline-class antibiotics and other complex therapeutic molecules.
• Antibiotic Research & Development: Used in R&D laboratories for creating and testing new antibiotic compounds with modified structures to combat resistant bacterial strains.
• Oncology Drug Discovery: Acts as a scaffold or intermediate in the development of targeted anti-cancer agents due to its complex, functionalized naphthacene core.
• Biochemical Research: Employed in academic and industrial research to study structure-activity relationships (SAR) of polycyclic compounds.
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes for complex active pharmaceutical ingredients (APIs).
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	11a-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,11a,12,12a-decahydro-3,5,10,12a-tetrahydroxy-6-methylene-1,11,12-trioxonaphthacene-2-carboxamide mono(toluene-p-sulphonate)
CAS No.	39649-76-8
Molecular Formula	C29H31ClN2O11S
Molecular Weight	651.08 g/mol
Synonyms	7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide p-toluenesulfonate; 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide 4-methylbenzenesulfonate; Minocycline p-toluenesulfonate; Minocycline tosylate; U-23,359; Minocycline toluenesulfonate salt
EINECS	Contact for details

Quality Control

Our production of 11a-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,11a,12,12a-decahydro-3,5,10,12a-tetrahydroxy-6-methylene-1,11,12-trioxonaphthacene-2-carboxamide mono(toluene-p-sulphonate) adheres to stringent quality protocols to ensure batch-to-batch consistency and compliance with pharmaceutical intermediate standards. All materials are subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.