Description

2,4(1H,3H)-PYRIMIDINEDIONE,1-[5-O-[BIS(4-METHOXYPHENYL)PHENYLMETHYL]-2-DEOXY-3-O-[(4-NITROPHENYL)SULFONYL]-β-D-THREO-PENTOFURANOSYL]-3-[(2,4-DIMETHOXYPHENYL)METHYL]-5-METHYL- is a sophisticated nucleoside analog derivative, engineered for advanced research and development in medicinal chemistry. This compound is a critical high-purity building block for the synthesis of novel oligonucleotides and therapeutic agents targeting genetic diseases. It is primarily utilized by pharmaceutical R&D teams, biotechnology firms, and academic research institutions focused on antisense oligonucleotide (ASO) development and nucleic acid chemistry.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A key protected intermediate for constructing therapeutic oligonucleotides designed to modulate gene expression.
• Pharmaceutical R&D: Serves as a critical precursor in the development of novel nucleoside-based drugs for antiviral and anticancer applications.
• Prodrug Development: Used in creating prodrug forms of nucleoside analogs to improve bioavailability and targeted delivery.
• Bioconjugation & Labeling: The reactive protecting groups facilitate site-specific conjugation with reporter molecules or targeting ligands.
• Academic Research: Enables fundamental studies in nucleic acid chemistry, enzyme mechanisms, and structure-activity relationships (SAR).
• Process Chemistry & Scale-up: Serves as a validated intermediate for the pilot-scale and commercial-scale manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2,4(1H,3H)-PYRIMIDINEDIONE,1-[5-O-[BIS(4-METHOXYPHENYL)PHENYLMETHYL]-2-DEOXY-3-O-[(4-NITROPHENYL)SULFONYL]-β-D-THREO-PENTOFURANOSYL]-3-[(2,4-DIMETHOXYPHENYL)METHYL]-5-METHYL-
CAS No.	290371-75-4
Molecular Formula	C48H47N3O13S
Molecular Weight	906.0 g/mol (approx.)
Synonyms	5-Methyl-2'-deoxyuridine derivative (DMT, Nosyl protected); 1-[(2R,3S,5R)-5-([Bis(4-methoxyphenyl)(phenyl)methoxy]methyl)-3-[(4-nitrophenyl)sulfonyl]oxyoxolan-2-yl]-3-[(2,4-dimethoxyphenyl)methyl]-5-methylpyrimidine-2,4-dione; 5'-O-DMT-2'-deoxy-3'-O-nosyl-5-methyluridine, 3-N-(2,4-dimethoxybenzyl) protected; Protected 2'-Deoxythymidine Intermediate; DMT-dT(Nos)-ODMBN; Nucleoside Phosphoramidite Precursor; ASO Synthesis Intermediate
EINECS	Contact for details

Quality Control

This high-value synthetic intermediate is manufactured under strict GMP-like conditions to ensure batch-to-batch consistency and purity suitable for pharmaceutical research. Every lot is subjected to comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes. Our quality system is designed to support regulatory filings for drug development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage (over 12 months), maintain under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.