Description

(2S,3S,4R,5R,6R)-6-[[[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-3,4,5-trihydroxy-oxane-2-carboxylic acid is a high-purity nucleotide derivative and a key intermediate in advanced biochemical synthesis. This compound is critical for research and development in nucleic acid chemistry, serving as a sophisticated building block for oligonucleotide synthesis. It is essential for pharmaceutical companies, biotechnology research institutions, and diagnostic developers working on next-generation therapeutics and molecular probes.

Application

• Oligonucleotide Synthesis: A vital phosphoramidite precursor for the solid-phase synthesis of DNA and RNA strands in research and therapeutic development.
• Antiviral & Anticancer Prodrug Development: Used as a sophisticated intermediate in the synthesis of nucleotide analog prodrugs targeting viral polymerases and cellular replication machinery.
• Biochemical Research: Employed in enzymatic studies, as a substrate analog, and for probing nucleic acid metabolism and related pathways.
• Diagnostic Probe Manufacturing: Integral for creating labeled nucleotides used in fluorescence in situ hybridization (FISH), PCR, and other molecular diagnostic assays.
• Messenger RNA (mRNA) Technology: Serves as a modified nucleotide precursor for creating stabilized mRNA constructs used in vaccine and protein replacement therapy platforms.
• Academic & Pharmaceutical R&D: A key reagent for exploring novel nucleoside chemistry and developing new chemical entities (NCEs) in drug discovery pipelines.

Basic Information

Product Name	(2S,3S,4R,5R,6R)-6-[[[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-3,4,5-trihydroxy-oxane-2-carboxylic acid
CAS No.	2616-64-0
Molecular Formula	C14H19N2O16P2
Molecular Weight	509.25 g/mol
Synonyms	Uridine 5'-diphosphoglucuronic acid (UDP-GlcUA); UDP-Glucuronic Acid; UDP-α-D-Glucuronic Acid; Uridine diphosphate glucuronic acid; Uridine 5'-(trihydrogen diphosphate) P'-α-D-glucuronosyl ester; UDP-α-D-GlcpA; UDP-GlcA; 1-UDP-α-D-glucuronic acid
EINECS	220-045-1

Quality Control

Our UDP-Glucuronic Acid is manufactured under strict quality systems suitable for research and pharmaceutical development. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS). We provide comprehensive Certificates of Analysis (COA) detailing purity, assay, and impurity profiles to ensure traceability and compliance with your project specifications. Our quality commitment supports applications requiring high-grade biochemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This material is hygroscopic (moisture-sensitive). For long-term storage, desiccate at low temperature. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay (Enzymatic)	≥ 90% (by weight)
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.