Description

Hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] [(3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl] hydrogen phosphate is a sophisticated nucleotide derivative and a key intermediate in the synthesis of modified nucleosides and nucleotides. This compound matters for its role in advanced pharmaceutical research, particularly in the development of antiviral and anticancer therapeutics, where precise molecular modifications are critical for efficacy. It is essential for research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleoside chemistry and prodrug development.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleoside analog prodrugs and antiviral agents.
• Biochemical Research: Used in enzymatic studies and as a substrate or inhibitor for kinases and other nucleotide-processing enzymes.
• Antiviral Drug Development: Serves as a precursor in the research and development of therapeutics targeting viral polymerases.
• Oncology Research: Investigated for the development of targeted cancer therapies that interfere with DNA/RNA synthesis.
• Prodrug Synthesis: Utilized to create masked phosphate derivatives (e.g., ProTides) to enhance cellular uptake and bioavailability of nucleoside drugs.
• Labeled Compound Synthesis: A starting material for the preparation of isotopically labeled (e.g., 13C, 15N, 32P) nucleotides for tracer studies.

Basic Information

Product Name	Hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] [(3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl] hydrogen phosphate
CAS No.	2147-59-3
Molecular Formula	C16H24N2O16P2
Molecular Weight	562.31 g/mol
Synonyms	Thymidine 5'-(α-D-glucopyranosyl hydrogen diphosphate); TDP-α-D-glucose; Thymidine diphosphate glucose; Thymidine 5'-diphospho-α-D-glucose; TDPG; TDP-Glc; α-D-Glucosyl thymidine diphosphate; 1-(5-O-{[(2R,3S,5R)-5-(4-Hydroxy-5-methyl-2-oxopyrimidin-1(2H)-yl)-3-hydroxyoxolan-2-yl]methyl} dihydroxyphosphoryloxyphosphoryl)-α-D-glucopyranose
EINECS	Contact for details

Quality Control

Our production of this high-purity nucleotide intermediate adheres to strict quality management systems. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, supporting compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.