Description

Hydroxyurea CAS NO 127-07-1 is a potent antineoplastic and antiviral agent, a hydroxylated derivative of urea. Its primary commercial value lies in its critical role as an active pharmaceutical ingredient (API) in the treatment of specific cancers and blood disorders. This compound is essential for pharmaceutical manufacturers and research institutions developing therapies for conditions such as chronic myeloid leukemia, sickle cell disease, and as a component in antiretroviral regimens. Consistent quality and reliable supply are paramount for its end-use in life-saving medications.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for oncology and hematology.
• Oncological Treatment: Used in the management of chronic myelogenous leukemia (CML), essential thrombocythemia, and polycythemia vera.
• Sickle Cell Disease Therapy: A key therapeutic agent to reduce the frequency of painful crises and the need for blood transfusions.
• Antiviral Research: Investigated for its role in potentiating the effects of certain antiretroviral drugs in HIV therapy.
• Biochemical Research: Utilized in laboratory studies as a ribonucleotide reductase inhibitor to synchronize cell cycles.
• Dermatological Applications: Employed in compounded formulations for severe, resistant psoriasis.

Basic Information

Product Name	Hydroxyurea
CAS No.	127-07-1
Molecular Formula	CH4N2O2
Molecular Weight	76.05 g/mol
Synonyms	Hydroxycarbamide; Carbamohydroxamic acid; N-Hydroxyurea; Litalir; Hydrea; Onco-Carbide; HU; SQ-1089; NSC-32065
EINECS	204-821-7

Quality Control

Our Hydroxyurea is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP and EP. Every batch undergoes comprehensive analytical testing including identification, assay, impurity profiling, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring full traceability and adherence to agreed specifications for pharmaceutical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Microbial Limits	Meets USP/EP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.