Description

6-Thioguanine is a sulfur-containing purine analog with significant biological activity. This compound matters for its critical role as an antimetabolite and immunosuppressive agent in advanced pharmaceutical research and development. It is primarily needed by the pharmaceutical industry for the synthesis of active pharmaceutical ingredients (APIs) and by research institutions conducting studies in oncology and immunology.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of chemotherapeutic agents and immunosuppressive drugs.
• Oncology Research: Used in biochemical and pharmacological studies targeting leukemia and other proliferative diseases.
• Biochemical Standard: Serves as a reference standard in analytical laboratories for quality control and method validation.
• Nucleic Acid Research: Employed in studies involving purine metabolism, DNA/RNA synthesis inhibition, and related enzymatic pathways.
• Immunology Studies: Investigated for its effects on immune cell proliferation and function in experimental models.

Basic Information

Product Name	6-Thioguanine
CAS No.	154-42-7
Molecular Formula	C5H5N5S
Molecular Weight	167.19 g/mol
Synonyms	2-Amino-6-mercaptopurine; 2-Amino-6-purinetiol; 6-Mercaptoguanine; Thioguanine; Lanvis; Tabloid; WR-1141; NSC-752
EINECS	205-827-0

Quality Control

Our 6-Thioguanine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to handle under an inert atmosphere for long-term storage and to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	Yellow to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.