Description

Cytarabine CAS NO 147-94-4 is a synthetic nucleoside analog and a cornerstone chemotherapeutic agent. Its primary value lies in its potent antimetabolite activity, which interferes with DNA synthesis in rapidly dividing cells. This product is essential for pharmaceutical manufacturers and research institutions focused on oncology, particularly in the formulation of injectable treatments for acute leukemias and other hematologic malignancies.

Application

• Oncological Pharmaceuticals: Primary active pharmaceutical ingredient (API) in injectable formulations for the treatment of acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), and other myeloproliferative disorders.
• Combination Chemotherapy: Used in critical treatment protocols such as "7+3" (with an anthracycline) for AML induction therapy.
• Intrathecal Chemotherapy: Formulated for administration into the cerebrospinal fluid to treat or prevent leukemic meningitis.
• Pharmaceutical Research & Development: Serves as a reference standard and key intermediate in the development of new antineoplastic agents and combination therapies.
• Biochemical Research: Used in cell biology and cancer research to study mechanisms of DNA synthesis inhibition, cell cycle arrest, and apoptosis.
• Generic Drug Manufacturing: Critical raw material for the production of cost-effective, high-quality generic cytarabine injections for global markets.

Basic Information

Product Name	Cytarabine
CAS No.	147-94-4
Molecular Formula	C9H13N3O5
Molecular Weight	243.22 g/mol
Synonyms	Cytosine Arabinoside; Ara-C; 1-β-D-Arabinofuranosylcytosine; Cytosar-U (brand name); Cytarabine Hydrochloride (salt form); Arabinofuranosylcytosine; 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone; NSC-63878
EINECS	205-705-9

Quality Control

Our Cytarabine is manufactured under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical applications. Each batch is tested against current pharmacopeial monographs (USP/EP) for identity, purity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA), detailing results for assay, related substances, residual solvents, and microbiological quality, is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store in a cool, dry place at controlled room temperature (15-25°C) or as specified on the label. For long-term stability, consider storage under inert atmosphere. Keep the container tightly sealed after each use to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 0.5 EU/mg (for injectable grade)
Microbial Enumeration	Complies with EP/USP for non-sterile substances

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.