Description

Deaza-Aminopterin is a structural analog of folic acid, belonging to the class of antimetabolites. This compound is significant for its role as a potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folate metabolism and nucleotide synthesis. It is primarily utilized by researchers in pharmaceutical development and life sciences for studying enzyme kinetics, metabolic pathways, and as a reference standard in analytical chemistry.

Application

• Biochemical Research: Used as a specific inhibitor of dihydrofolate reductase (DHFR) in enzymatic and cellular studies.
• Pharmaceutical R&D: Serves as a reference compound and intermediate in the development of novel antifolate and chemotherapeutic agents.
• Metabolic Pathway Analysis: Employed to investigate folate metabolism and its role in cell proliferation and DNA synthesis.
• Academic Research: Utilized in university and institutional laboratories for fundamental studies in biochemistry and molecular biology.
• Analytical Standard: Acts as a high-purity reference material for method development and quality control in HPLC, LC-MS, and other analytical techniques.

Basic Information

Product Name	Deaza-Aminopterin
CAS No.	18921-68-1
Molecular Formula	C₁₉H₂₀N₈O₅
Molecular Weight	440.41 g/mol
Synonyms	10-Deazaaminopterin; 10-Deaza-aminopterin; 4-Amino-10-deazapteroylglutamic acid; 4-Amino-4-deoxy-10-deazapteroic acid; NSC 127755; 10-DAM; Deaza-aminopterin
EINECS	Contact for details

Quality Control

Our Deaza-Aminopterin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent in-house specifications. We are committed to supplying materials that meet the exacting requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.