Description

3',5'-Dibromoaminopterin is a halogenated derivative of the classic antifolate aminopterin, designed for enhanced biochemical research and pharmaceutical development. This compound is valued for its potent inhibitory activity against dihydrofolate reductase (DHFR), making it a critical tool for studying folate metabolism and cell proliferation pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology research, enzyme inhibition studies, and the development of novel chemotherapeutic agents.

Application

• Biochemical Research: As a potent and selective inhibitor of dihydrofolate reductase (DHFR) for mechanistic and kinetic studies.
• Oncology Research: Investigation of antifolate mechanisms and evaluation of potential chemotherapeutic activity in various cancer cell lines.
• Enzyme Profiling: Used in high-throughput screening (HTS) assays to identify and characterize new DHFR inhibitors.
• Pharmaceutical Intermediate: Serves as a key synthetic precursor or analog in the development of novel targeted therapies.
• Academic Studies: Employed in university laboratories for teaching and advanced research in medicinal chemistry and molecular biology.

Basic Information

Product Name	3',5'-Dibromoaminopterin
CAS No.	1948-22-7
Molecular Formula	C₁₉H₁₈Br₂N₈O₅
Molecular Weight	598.20 g/mol
Synonyms	2,4-Diamino-6-[[(3,5-dibromo-4-aminophenyl)methyl]amino]pteridine-7(8H)-one; 3,5-Dibromo-4-aminopteroylglutamic Acid; 3,5-Dibromoaminopterin; 4-Amino-3,5-dibromobenzoyl-L-glutamic Acid 2,4-Diaminopteridine-6-ylmethyl Amide; N-[4-[(2,4-Diamino-6-pteridinyl)methyl]-3,5-dibromoaniline]benzoyl-L-glutamic Acid
EINECS	Contact for details

Quality Control

Our 3',5'-Dibromoaminopterin is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for research applications. All materials are subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing specific test results is provided with each shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.