Description

Tegafur is a fluorinated pyrimidine derivative and a prodrug of the chemotherapeutic agent 5-fluorouracil (5-FU). This compound is of significant importance in oncology for its role in targeted cancer therapy, offering a mechanism for the controlled release of the active cytotoxic metabolite. It is primarily needed by pharmaceutical manufacturers and research institutions engaged in the development and production of antineoplastic medications, particularly for the treatment of gastrointestinal and breast cancers. The product referenced here is Tegafur CAS NO 17902-23-7.

Application

• Active Pharmaceutical Ingredient (API): Primary use as the key component in oral chemotherapeutic formulations.
• Oncology Drug Development: Serves as a critical raw material in R&D for novel combination therapies and prodrug delivery systems.
• Combination Chemotherapy: Used in fixed-dose combination drugs, such as those with gimeracil and oteracil (S-1 regimen), to enhance efficacy and reduce side effects.
• Pharmaceutical Research: Utilized in preclinical and clinical studies to investigate pharmacokinetics, metabolism, and new treatment protocols.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical laboratories.

Basic Information

Product Name	Tegafur
CAS No.	17902-23-7
Molecular Formula	C8H9FN2O3
Molecular Weight	200.17 g/mol
Synonyms	5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione; FT-207; Ftorafur; 1-(Tetrahydro-2-furanyl)-5-fluorouracil; NSC-148958; Fluorofur; Futraful; Sunfural
EINECS	Contact for details

Quality Control

Our Tegafur is manufactured and tested under strict quality management systems. We ensure compliance with ICH Q7 guidelines and relevant pharmacopeial standards for active pharmaceutical ingredients (APIs). Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.