Description

[[(2R,3R,4R,5R)-5-(6-Amino-2-Chloro-Purin-9-Yl)-3,4-Dihydroxy-Oxolan-2-Yl]Methoxy-Hydroxy-Phosphoryl]Oxyphosphonic Acid CAS NO 16506-88-0 is a high-purity, chemically defined nucleotide analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block or intermediate for synthesizing modified nucleosides and nucleotides, which are essential for probing biological mechanisms and developing novel therapeutics. It is primarily required by research institutions, biotechnology firms, and pharmaceutical companies engaged in antiviral drug discovery, oncology research, and the study of nucleic acid biochemistry.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand polymerase and kinase functions.
• Proteomics & Genomics: Serves as a modified building block for oligonucleotide synthesis in probe development and diagnostic assays.
• Drug Discovery: Integral for structure-activity relationship (SAR) studies to optimize the potency and selectivity of candidate drugs.
• Academic Research: Employed in university and institutional labs for fundamental studies on nucleotide metabolism and signaling pathways.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in regulatory filings.

Basic Information

Product Name	[[(2R,3R,4R,5R)-5-(6-Amino-2-Chloro-Purin-9-Yl)-3,4-Dihydroxy-Oxolan-2-Yl]Methoxy-Hydroxy-Phosphoryl]Oxyphosphonic Acid
CAS No.	16506-88-0
Molecular Formula	C11H15ClN5O11P2
Molecular Weight	497.70 g/mol
Synonyms	2-Chloroadenosine 5'-(tetrahydrogen triphosphate); 2-Cl-ATP; 2-Chloro-ATP; 2-Chloroadenosine-5'-triphosphate; Adenosine-5'-triphosphate, 2-chloro-; 2-Chloro-adenosine-5'-triphosphoric acid; [(2R,3S,4R,5R)-5-(6-Amino-2-chloro-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl phosphono hydrogen phosphate
EINECS	Contact for details

Quality Control

Our production of this nucleotide analog adheres to stringent quality management systems. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specification parameters is provided with each shipment. We support development and commercial projects requiring material that meets the exacting standards for pharmaceutical research and GMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.