Description

5'-Oleoyl Cytarabine is a lipophilic prodrug derivative of the established antimetabolite cytarabine. This chemical modification is designed to enhance cellular uptake and bioavailability, addressing key challenges in drug delivery. It is primarily utilized in advanced pharmaceutical research and development, particularly for creating novel therapeutic formulations targeting oncology and other critical disease areas.

Application

• Pharmaceutical R&D: As a key intermediate in the development of novel prodrugs and liposomal drug delivery systems.
• Oncology Research: For investigating improved formulations of cytarabine with potentially enhanced efficacy and reduced systemic toxicity.
• Drug Delivery Studies: Used in academic and industrial labs to study the impact of lipophilicity on membrane permeability and pharmacokinetics.
• Preclinical Development: Serves as a critical material for in vitro and in vivo studies to establish proof-of-concept for new therapeutic entities.
• Bioconjugation Chemistry: Acts as a building block for synthesizing more complex targeted drug conjugates.

Basic Information

Product Name	5'-Oleoyl Cytarabine
CAS No.	101235-34-1
Molecular Formula	C33H55N3O8
Molecular Weight	621.81 g/mol
Synonyms	1-β-D-Arabinofuranosylcytosine 5'-oleate; Cytarabine 5'-O-oleate; Cytosine Arabinoside 5'-Oleoyl Ester; 5'-O-Oleoyl-1-β-D-arabinofuranosylcytosine; N4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone 5'-Oleate; Ara-C 5'-Oleate; Lipophilic Cytarabine Derivative
EINECS	Contact for details

Quality Control

Our 5'-Oleoyl Cytarabine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.