Description

5-Chloro-5,8-Dideazaisofolic Acid is a specialized heterocyclic compound that serves as a key intermediate in advanced pharmaceutical synthesis. This compound matters for its role in the research and development of novel therapeutic agents, particularly in the field of antifolate and antimetabolite drug discovery. It is primarily needed by R&D laboratories, pharmaceutical manufacturers, and fine chemical suppliers engaged in producing high-value active pharmaceutical ingredients (APIs) and reference standards.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel antifolate and antimetabolite drug candidates.
• Biochemical Research: Used as a reference standard or tool compound in enzymatic and cellular studies targeting folate pathways.
• Preclinical Development: Serves as a key starting material for the preparation of compounds for pharmacological evaluation and toxicity studies.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for specialized, high-purity chemical entities.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry projects and mechanism-of-action studies.

Basic Information

Product Name	5-Chloro-5,8-Dideazaisofolic Acid
CAS No.	102743-78-2
Molecular Formula	C19H18ClN5O4
Molecular Weight	415.83 g/mol
Synonyms	5-Chloro-5,8-dideazafolic acid; 5-Chloro-5,8-dideazapteroylglutamic acid; 2-[[4-[(2-Amino-5-chloro-4-oxo-1,6-dihydro-6-pteridinyl)methyl]amino]benzoyl]amino]pentanedioic acid; 5-Cl-DDATHF analog; 5-Chloro-DDATHF; Antifolate intermediate; 5-Chloro-5,8-dideazaaminopterin derivative
EINECS	Contact for details

Quality Control

Our 5-Chloro-5,8-Dideazaisofolic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.